Here you find publications involving the graduate students (marked in bold) of the Marburg School of Microbiology.

2019 _

Rossmann FM, Rick T, Mrusek D, Sprankel L, Leomhard T, Dörrich AK, Bubendorfer S, Kaever V, Bange G, Thormann KM (2019). The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP.  Journal of Bacteriology, 2019 Jan 22. pii: JB.00534-18. doi: 10.1128/JB.00534-18.

Han X, Altegoer F, Steinchen W, Binnebesel L, Schuhmacher J, Glatter T, Giammarinaro PI, Djamei A, Rensing SA, Reissmann S, Kahmann R, Bange G. 2019. A kiwellin disarms the metabolic activity of a secreted fungal virulence factor. Nature 565(7741):650-653. doi: 10.1038/s41586-018-0857-9.


2018 _

Bernhardsgrütter I, Vögeli B, Wagner T, Dominik P, Cortina NS, Bange G, Engliberge S, Girard E, Riobé F, Maury O, Shima S, Zarzycki J, Erb TJ. (2018). The multi-catalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite. Nature Chemical Biology, Accepted

Brenzinger S, Pecina A, Mrusek D, Mann P, Völse K, Wimmi S, Ruppert U, Becker A, Ringgaard S, Bange G, Thormann K (2018). ZomB is essential for flagellar motor reversals in Shewanella putrefaciens and Vibrio parahaemolyticus. Molecular Microbiology, 109(5):694-709

Gratani FL, Horvatek P, Geiger T, Borisova M, Mayer C, Grin I, Wagner S, Steinchen W, Bange G, Velic A, Maček B, Wolz C (2018). C-terminal domain regulates the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional Rel/SpoT enzyme from Staphylococcus aureus. PLOS Pathogens, 9;14(7):e1007514.

Karniel A, Mrusek D, Steinchen W, Dym O, Bange G, Bibi E (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle (SRP)- receptor. Journal of Molecular Biology, 430(11):1607-1620

Steinchen W, Vogt M, Altegoer F, Giammarinaro P, Horvatek P, Wolz C, Bange G (2018). Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ. Scientific Reports, 8(1):2195

Quax TEF, Altegoer F, Rossi F, Li Z, Rodriguez-Franco M, Kraus F, Bange G*, Albers SV* (2018). "Structure and function of the archaeal response regulator CheY. PNAS, 115(6):E1259-E1268; * Joint corresponding authors

Czech L, Hermann L, Stöveken N, Richter A, Hoeppner A, Smits SHJ, Heider J, Bremer E. (2018). Role of the extremolytes ectoine and hydroxyectoine as stress protectants and nutrients: genetics, phylogenomics, biochemistry, and structural analysis. Genes 9, 177

Hakobyan A, Liesack W, Glatter T. 2018. Crude-MS strategy for in-depth proteome analysis of the methane-oxidizing Methylocystis sp. strain SC2. J. Proteome Res. 17, 3086-3103.

Donati S, Sander T, and Link H (2017) Crosstalk between transcription and metabolism: how much enzyme is enough for a cell? Wiley Interdisciplinary Reviews: Systems Biology and Medicine. doi: 10.1002/wsbm.1396. [Epub ahead of print]      



2017 _

Guder JC, Schramm T, Sander T, and Link H.(2017) Time-Optimized Isotope Ratio LC–MS/MS for High-Throughput Quantification of Primary Metabolites. Analytical chemistry 89 (3), 1624-1631, 6.  

Czech L, Poehl S, Hub P, Stoeveken N, Bremer E (2017) Tinkering with osmotically controlled transcription allows enhanced production and excretion of ectoine and hydroxyectoine from a microbial cell factory. Appl. Environ. Microbiol. (in press)

Schulz A, Hermann L, Freibert S, Bönig T, Hoffmann T, Riclea R, Dickschat J, Heider J, Bremer E (2017) Transcriptional regulation of ectoine catabolism in response to multiple metabolic and environmental cues. Env. Microbiol. 19: 4599-4619

Schäper S*, Steinchen W*, Krol E, Altegoer F, Skotnicka D, Søgaard-Andersen L, Bange G, Becker A (2017). AraC-like transcriptional activator CuxR binds c-di-GMP by a PilZ-like mechanism to regulate extracellular polysaccharide production. PNAS 114(24):E4822-E4831; *Equally contributing authors

Vera MAG, Brune, A. (2017) Hand over that gun: lateral gene transfer provides an amoeba with a bacterial weapon. Environ. Microbiol. 19: 847–848

Tegtmeier D, Belitz A, Radek R, Heimerl T, Brune A (2017) Ereboglobus luteus gen. nov. sp. nov. from cockroach guts, and new insights into the oxygen relationship of the genera Opitutus and Didymococcus (Verrucomicrobia: Opitutaceae)Syst. Appl. Microbiol. (in press)

Zheng H, Dietrich C, Brune A (2017) Genome analysis of Endomicrobium proavitum suggests loss and gain of relevant functions during the evolution of intracellular symbionts. Appl. Environ. Microbiol. 83: e00656–17

Pausch P, Müller-Esparza H, Gleditzsch D, Altegoer F, Randau L, Bange G (2017). Structural variation of type I-F CRISPR RNA guided DNA surveillance. Molecular Cell, 67(4):622-632

Singh PK, Bartalomej S, Hartmann R, Jeckel JH, Vidakovic L, Nadell CD, Drescher K (2017). Vibrio cholerae combines individual and collective sensing to trigger biofilm dispersal Current Biology 27, 1-8

Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN (2017). Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization. EMBO Journal doi: 10.15252/embj.201696189; 

Gessner C, Steinchen W, Bedard S, Skinner JJ, Woods VL, Walsh TJ, Bange G, Pantazatos D (2017). Computational method allowing hydrogen-deuterium exchange mass spectrometry at single amide resolution. Scientific Reports, doi:10.1038/s41598-017-03922-3

Piepenbreier H, Fritz G, and Gebhard S (2017). Transporters as information processors in bacterial signalling pathways. Mol. Microbiol.104(1), 1-15

Schulz A, Stöveken N, Binzen I, Hoffmann T, Heider J, Bremer E (2017) Feeding on compatible solutes: a substrate-induced pathway for uptake and catabolism of ectoines and its genetic control by EnuR. Env. Microbiol. 19: 926-946.

2016 _

Bedrunka P, Graumann PL (2016). Subcellular clustering of a putative c-di-GMP-dependent exopolysaccharide machinery affecting macro clolony architecture in B. subtilis. Environ Microbiol Rep. doi: 10.1111/1758-2229.12496

Schindler D, Milbredt S, Sperlea T, Waldminghaus T (2016). Design and Assembly of DNA Sequence Libraries for Chromosomal Insertion in Bacteria Based on a Set of Modified MoClo Vectors. ACS Synth Biol. 5(12):1362-1368.

Ma H, Zhang F, Ignatz E, Suehnel M, Xue P, Scheerer P, Essen L, Krauß N, Lamparter T (2016). Divalent Cations Increase DNA Repair Activities of Bacterial (6-4) Photolyases. Photochem Photobiol. doi: 10.1111/php.12698.

Milbredt S, Farmani N, Sobetzko P, Waldminghaus T (2016). DNA Replication in Engineered Escherichia coli Genomes with Extra Replication Origins. ACS Synth Biol. 5(10):1167-1176.

Dempwolff F, Schmidt FK, Hervás AB, Stroh A, Rösch TC, Riese CN, Dersch S, Heimerl T, Lucena D, Hülsbusch N, Stuermer CA, Takeshita N, Fischer R, Eckhardt B, Graumann PL (2016) Super Resolution Fluorescence Microscopy and Tracking of Bacterial Flotillin (Reggie) Paralogs Provide Evidence for Defined-Sized Protein Microdomains within the Bacterial Membrane but Absence of Clusters Containing Detergent-Resistant Proteins. PLoS Genet. 12(6):e1006116

von Zadow A, Ignatz E, Pokorny R, Essen LO, Klug G (2016). Rhodobacter sphaeroides CryB is a bacterial cryptochrome with (6-4) photolyase activity. FEBS Journal 283(23):4291-4309

Altegoer F, Rensing SA, Bange G (2016). Structural basis for the CsrA-dependent modulation of translation initiation by an ancient regulatory protein. PNAS, 113(36):10168-73

Steinchen W, Schuhmacher J, Altgoer F, Fage CD, Srinivasan V, Linne U, Marahiel M, Bange G (2015). Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone. PNAS, 112(43):13348-53

Döhlemann J, Brennecke M, Becker A (2016) Cloning-free genome engineering in Sinorhizobium meliloti advances applications of Cre/loxP site-specific recombination. J Biotechnol 233:160-170.

Blauenburg B, Mielcarek A, Altegoer F, Fage CD, Linne U, Bange G, Marahiel MA (2016). Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU. PLoS One. 11(7):e0158749.

Steinchen W & Bange G (2016) The magic dance of the nutritional alarmones (p)ppGpp. Molecular Microbiology, 101(4):531-44

Gulbronson CJ, Ribardo DA, Balaban M, Knauer C, Bange G, Hendrixson DR (2016). FlhG employs diverse intrinsic domains and influences FlhF GTPase activity to numerically regulate polar flagellar biogenesis in Campylobacter jejuni. Mol Microbiol. 99(2):291-306.

Lacanna E, Bigosch C, Kaever V, Boehm A, Becker A (2016) Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes. J Bacteriol 198: 2524-2535.

Frage B, Döhlemann J, Robledo M, Lucena D, Sobetzko P, Graumann PL, Becker A (2016) Spatiotemporal choreography of chromosome and megaplasmids in the Sinorhizobium meliloti cell cycle. Mol Microbiol 100:808-823.

Schäper S, Krol E, Skotnicka D, Kaever V, Hilker R, Søgaard-Andersen L, Becker A (2016) Cyclic di-GMP regulates multiple cellular functions in the symbiotic α‑proteobacterium Sinorhizobium meliloti. J Bacteriol 198:521-535.

Messerschmidt SJ, Schindler D, Zumkeller CM, Kemter FS, Schallopp N, Waldminghaus T (2016). Optimization and Chraracterization of the Synthetic Secondary Chromosome synVicII in Escherichia coli. Frontiers in Bioengineering and Biotechnology


2015 _

Schuhmacher JS, Rossmann F, Dempwolff F, Knauer C, Altegoer F, Steinchen W, Dorrich A, Klingl A, Stephan M, Linne U, Thormann K, Bange, G (2015) The MinD-like ATPase FlhG effects location and number of bacterial flagella during C-ring assembly. PNAS, 112(10):3092-7

El Andari J, Altegoer F, Bange G, Graumann PL (2015). Bacillus subtilis Bactofilins Are Essential for Flagellar Hook- and Filament Assembly and Dynamically Localize into Structures of Less than 100 nm Diameter underneath the Cell Membrane. PLoS One. 10(10):e0141546.

Robledo M, Frage B, Wright PR, Becker A (2015) A stress-induced small RNA modulates alpha-rhizobial cell cycle progression. PLoS Genetics 11: e1005153.

Messerschmidt SJ, Kemter FS, Schindler D, Waldminghaus T (2015). Synthetic secondary chromosomes in Escherichia coli based on the replication origin of chromosome II in Vibrio cholerae. Biotechnol J. 10(2):302-14.

Ritter C, Nett N, Acevedo-Rocha CG, Lonsdale R, Kräling K, Dempwolff F, Hoebenreich S, Graumann PL, Reetz MT, Meggers E (2015) Bioorthogonal Enzymatic Activation of Caged Compounds. Angew. Chem. Int. Ed. Engl. 54: 13440-13443

Altegoer F, Bange G (2015). Undiscovered regions on the molecular landscape of flagellar assembly. Curr Opin Microbiol. 28:98-105.

Pausch P, Singh U, Ahmed YL, Pillet B, Murat G, Altegoer F, Stier G, Thoms M, Hurt E, Sinning, I, Bange, G, Kressler D* (2015) Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones. Nature Communications, 6:7494

Schindler D, Waldminghaus T (2015). Synthetic chromosomes. FEMS Microbiol Rev. 39(6):871-91.

Schlüter JP, Czuppon P, Schauer O, Pfaffelhuber P, McIntosh M, Becker A (2015) Classification of phenotypic subpopulations in isogenic bacterial cultures by triple promoter probing at single cell level. J Biotechnol 198: 3-14.

Rösch, T Graumann, P L (2015) Induction of Plasmid Conjugation in Bacillus subtilis Is Bistable and Driven by a Direct Interaction of a Rap/Phr Quorum-sensing System with a Master Repressor. J. Biol. Chem. 290: 20221-20232

Rossmann F, Brenzinger S, Knauer C, Dörrich AK, Bubendorfer S, Ruppert U, Bange G, Thormann KM (2015). The role of FlhF and HubP as polar landmark proteins in Shewanella putrefaciens CN-32. Mol Microbiol. 98(4):727-42.

Schuhmacher JS, Thormann KM, Bange G (2015). How bacteria maintain location and number of flagella? FEMS Microbiol Rev. 39(6):812-22.

Giessen TW, Altegoer F, Nebel AJ, Steinbach RM, Bange G, Marahiel MA (2016). A synthetic adenylation-domain-based tRNA-aminoacylation catalyst. Angew Chem Int Ed Engl. 54(8):2492-6.

Charoenpanich P, Soto MJ, Becker A, McIntosh M (2015) Quorum sensing restrains growth and is rapidly inactivated during domestication of Sinorhizobium meliloti. Environ Microbiol Rep 7: 373-382.

Becker A, Overlöper A, Schlüter JP, Reinkensmeier R, Robledo M, Giegerich R, Narberhaus F, Evguenieva-Hackenberg E (2014) Riboregulation in plant-associated alpha-proteobacteria. RNA Biol 11: 550-562.


2014 _

Messerschmidt SJ, Waldminghaus T (2014). Dynamic organization: chromosome domains in Escherichia coli. J Mol Microbiol Biotechnol. 2014;24(5-6):301-15.

Völker T, Dempwolff F, Graumann PL, Meggers E. (2014) Progress towards Bioorthogonal Catalysis with Organometallic Compounds. Angew. Chem. Int. Ed. Engl. 53, 10536-10540

Altegoer F, Schuhmacher J, Pausch P, Bange G (2014). From molecular evolution to biobricks and synthetic modules: a lesson by the bacterial flagellum. Biotechnol Genet Eng Rev. 30(1-2):49-64.

Torres-Quesada O, Reinkensmeier J, Schlüter J-P, Robledo M, Peregrina A, Giegerich R, Toro N, Becker A, Jiménez-Zurdo JI (2014) Genome-wide profiling of Hfq-binding RNAs uncovers extensive post-transcriptional rewiring of major stress response and symbiotic regulons in Sinorhizobium meliloti. RNA Biol 11: 563-579.

Becker A, Overlöper A, Schlüter JP, Reinkensmeier R, Robledo M, Giegerich R, Narberhaus F, Evguenieva-Hackenberg E (2014) Riboregulation in plant-associated alpha-proteobacteria. RNA Biol 11: 550-562.

Baumgardt K, Charoenpanich P, McIntosh M, Schikora A, Stein E, Thalmann S, Kogel K-H, Klug G, Becker A, Evguenieva-Hackenberg E (2014) RNase E affects the expression of the acyl-homoserine lactone synthase gene sinI in Sinorhizobium meliloti. J Bacteriol 196:1435-1447.

2013 _

Pini F, Frage B, Ferri L, De Nisco NJ, Moapatra S, Taddei L, Firoavanti A, Dewitte F, Galardini M, Brilli M, Villeret V, Bazzicalupo M, Mengoni A, Walker GC, Becker A, Biondi EG (2013) The essential DivJ/CbrA kinase and PleC phosphatase system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti. Mol Microbiol 90: 54-71.

Charoenpanich P, Meyer S, Becker A, McIntosh M (2013) Temporal expression program of quorum sensing-based transcription regulation in Sinorhizobium meliloti. J Bacteriol 195: 3224-3236.

Schlüter JP, Reinkensmeier J, Barnett MJ, Lang C, Krol E, Giegerich R, Long SR, Becker A (2013) Global mapping of transcription start sites and promoter motifs in the symbiotic a-proteobacterium Sinorhizobium meliloti1021. BMC Genomics 14: 156.

2012 _

Sobrero P, Schlüter JP, Lanner U, Schlosser A, Becker A, Valverde C (2012) Quantitative proteomic analysis of the Hfq-regulon in Sinorhizobium meliloti 2011. PLoS One 7: e48494.